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Fast-twitch muscle fibres are particularly important for strength and functional movement, yet they are often the first to atrophy during periods of inactivity or calorie restriction

Oxidative stress is recognized as a key driver of endothelial damage and vascular stiffness, which are fundamental contributors to hypertension and other cardiovascular conditions [91]

In contrast, levels of kynurenine pathway metabolites 3-HK, 3-AA, QUIN, and PIC were decreased in ME/CFS [109]

This article is part of the PlexusDx Education Hub practical, evidence-based guidance on GLP-1 therapies, weight management protocols, and the genetic factors behind every metabolic decision