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The SURMOUNT-5 trial, published in The New England Journal of Medicine , directly compared tirzepatide to semaglutide and found tirzepatide produced 47% greater relative weight loss at 72 weeks, 20.2% of body weight versus 13.7%

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Remove particulates from the concentrated sample using a 0.22 m filter unit, or centrifuge the sample at 4,000 g for 20 min

Notably, integrating ctDNA analysis with the detection of mutations associated with metabolic dysregulation, such as KRAS and BRAF, has been shown to enhance diagnostic sensitivity [137]

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