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Once you escalate beyond 2mg per week, the 5mg vial becomes impractical because you burn through it too quickly

This could cause a relative biotin deficiency and have an influence on the skin

Patients with Leber's Disease: Vitamin B12 levels may exacerbate optic nerve atrophy

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One Cochrane review found that high-dose oral vitamin B12 supplements (1,000 mcg to 2,000 mcg per day) was as effective for correcting megaloblastic anemia as B12 shots