Preclinical studies demonstrate GIP signaling can attenuate GLP-1-induced nausea pathways
These drugs activate the peroxisome proliferatoractivated receptors, which regulate how the body metabolizes lipids, and thus are theoretically good targets for treatment of Type 2 diabetes
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Patients achieving at least a 5% reduction from baseline to week 68 in body weight was a co-primary outcome in the STEP 1 to STEP 4 studies, and patients achieving at least 10%, 15%, or 20% reductions were confirmatory secondary outcomes in some studies and supportive secondary outcomes in others (Table 14)
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