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The modulating effect of LC on the studied monoamines could be attributed to its ability to prevent neuronal loss by inhibiting ROS-mediated reactions via the reduction of microglial activation and the related production of oxygen intermediates and inflammatory factors (Essawy et al
doi: 10.1016/j.cmet.2006.01.004 5 RyanDHAcostaA
& Groeneveld, G
Since PAI-1 exists in significant excess relative to tissue plasminogen activator (tPA) in plasma, even modest reductions could meaningfully improve the body ability to clear clots
2015;95:E2629
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