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245,246 Hence, GLP-1 activates -cells and promotes somatostatin secretion, forming a multi-layered inhibitory mechanism that effectively reduces glucagon secretion
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HR = 0.88
3.4 Tirzepatide restores -cell function through upregulation of FOXO1 Given that FOXO1 serves as a central regulator of the FOXO pathway and plays a critical role in maintaining -cell identity, oxidative defense, and insulin gene expression [6], we then examined the levels of FOXO1 and its phosphorylation state (p-FOXO1) in -cell
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