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At the basolateral membrane, NBC1 (Na + -bicarbonate cotransporter 1: encoded by the SLC4A4 gene) effluxes HCO 3 , made de novo intracellularly via CAII, to the blood

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Its protective effects are primarily mediated through antioxidant and anti-inflammatory properties, as well as by modulating pathways such as RIP1/RIP3/MLKL, AKT/mTOR, and miR-22-3p/DPP4

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This concern is particularly relevant given the increasing prevalence of gout, a painful form of arthritis linked to high uric acid levels in the blood