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When comparing cagrilintide and sCT at the doses of 3 nmol/kg in WT and KO mice, cagrilintide significantly activated fewer neurons in the AP (75%

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A faster metabolism might slightly shorten the effective window

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Switching to tirzepatide, even at a higher monthly cost, may actually save money long-term if it produces the metabolic improvements that semaglutide could not

This is the same logic that produced CagriSema (cagrilintide + semaglutide)