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Early weight loss responders to liraglutide 3.0 mg achieved greater weight loss and regression to normoglycaemia, and reduced development of T2D at 3 years, versus early nonresponders in the SCALE obesity and prediabetes trial [abstract]
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& Yellon, D
Additional observations included decreases in body mass index (BMI), waist circumference, fasting plasma glucose, HbA1c, and blood pressure
While GLP-1 and next-generation obesity therapies have become widely recognized for their role in weight management, the Company believes maintaining lean muscle mass during obesity-related weight loss may become an increasingly important area of product development and clinical focus
At the same time, it clearly highlights the limit: effects are moderate, gradual and in no way comparable to drugs that directly and long-term activate GLP-1 receptors [1][3][5]
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