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Several studies have shown that PACAP is a powerful stimulator of insulin secretion, which enhances glucose uptake in adipocytes and augments antilipolytic action of insulin (86, 87)

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doi:10.1128/MCB.23.1.104-118.2003

People carrying certain genetic variants may require higher doses or dual-compound therapy to achieve the same appetite suppression as others

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Obtaining injections outside regulated NHS settings may involve inappropriate dosing, lack of monitoring, non-sterile technique, and unnecessary financial cost without clinical benefit