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Organ growth concerns (acromegaly-like effects) are theoretically possible with chronic supraphysiological IGF-1 exposure, though no human studies document this outcome at research doses below 100 mcg daily for fewer than 12 weeks

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Conflicting messages reduce confidence and increase avoidable contacts

Cell 167:1339-1353.e21

GLP-1 receptor agonists are particularly beneficial for individuals requiring significant weight loss and metabolic improvements