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These findings underscore the critical need for highly bioavailable, systemic antioxidant support

Protein signal quantification was done with ImageJ (National Institutes of Health)

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Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H 2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years