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2- Specificity and side-effect profile: Ipamorelin is comparatively selective for GH with minimal cortisol/ACTH or prolactin rise, reducing some off-target endocrine effects seen with older GHRPs

Given that an increase, but not a decrease, in the Kyn/Trp ratio is expected to be associated with inflammation, and that we observe a one-directional trend towards increased values among the asymptomatic V30M carriers compared to controls (Table 2

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Older Adults (50+) : May need to use the standard or advanced doses of GHSs (Sermorelin, Ipamorelin ) to achieve the same GH pulse that a younger person gets from a beginner dose