These differences do not seem to be secondary to global changes in renal permeability, as urinary protein concentrations (normalized to urine creatinine levels) were unchanged (Figure 4D)
1,2 The results are consistent with actions taken by the European Medicines Agency (EMA) in June 2025, when the agency classified NAION as a very rare side effect of semaglutide and recommended product labeling updates. Epidemiologic data reviewed by the EMA suggested an approximately twofold increased risk in adults with type 2 diabetes, corresponding to roughly one additional case per 10,000 person-years of treatment. The agency advised that patients with sudden vision loss or rapidly worsening eyesight seek immediate medical attention and discontinue treatment if NAION is confirmed. READ MORE: Blinding Disease-Weight Loss Drug Link: EMA Announces Start of Semaglutide Investigation Study strengths Methodologically, the VA study offers several strengths: The analysis leveraged the largest integrated health care system in the United States, with medication exposure confirmed through pharmacy dispensing records rather than prescription data alone
Moreover, its written in lay terms so the average person can understand it without too much scientific jargon
Focus on protein-rich foods, non-starchy vegetables, and hydration to manage increased appetite naturally
The question of GLP-1 use during breastfeeding has specific considerations that require medical consultation
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