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In addition, drug repurposing, which involves investigation of existing drugs for new therapeutic purposes, particularly uses biophysics-based molecular docking approaches and has been proven to be effective and efficient and of immense value in biomedicine (184, 187)

Impaired synaptic plasticity and decreased excitability of hippocampal glutamatergic neurons mediated by BDNF downregulation contribute to cognitive dysfunction in mice induced by repeated neonatal exposure to ketamine

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A common approach is 8-12 weeks active, 8 weeks off, then reassess whether another cycle is needed