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APAP can be synthesized in the body through O-dealkylation of the prodrug phenacetin, a pain-killer that was withdrawn from the market due to nephrotoxicity and carcinogenesis [3]

While beneficial for healing, this theoretical concern exists for those with cancer history or active malignancy

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Preclinical Studies in Ototoxicity Models A study carried out both in cultured cells and in an animal model (male and female mice) demonstrated the strong beneficial potential of ALA in rescuing ototoxic hearing loss caused by cisplatin