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Reactive oxygen species (ROS: e.g., hydroxyl radicals (OH.), ozone (O 3 ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), superoxide anion (O 2 )) 15,16,17,18 and reactive nitrogen species (RNS: e.g., nitric oxide (NO), dinitrogen tetroxide (N 2 O 4 ), dinitrogen pentoxide (N 2 O 5 )) 18,19 can be found in plasma