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Pernicious Anemia: This is an autoimmune disorder where the body mistakenly attacks a protein in the stomach called "intrinsic factor." Without this protein, you simply cannot absorb B12 from food, making injections a lifelong necessity

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Several efflux pumps, such as P-glycoprotein (P-gp) and organic anion transporters, can actively remove these therapeutics out of the CNS

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