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Our observation of a widespread induction of pathways required for viral replication in uninfected cells, in combination with the previous detection of extracellular vesicles containing viral proteins in SARS-CoV-2 infected individuals 62,63 indicate that SARS-CoV-2 infected cells might modulate the permissibility of their microenvironment for viral replication in a similar manner

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For instance, cyclic-AMP (cAMP) is one of the upstream signals that regulate both mitochondrial biogenesis and mitophagy

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Simkin AJ, Guirimand G, Papon N et al (2011) Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta