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However, it is not possible to confirm it is the strongest weight loss medicine until more research and comparisons with approved treatments are available

Side effects were generally dose-dependent starting on a lower dose and gradually increasing may help reduce gastrointestinal discomfort

View Source LANCET DIABETES & ENDOCRINOLOGY Effects of retatrutide on body composition in people with type 2 diabetes 2025 Coskun T, et al

Retatrutide Retatrutide targets: GLP-1 receptor GIP receptor Glucagon receptor The addition of glucagon receptor activity introduces another layer of biological complexity

The findings were also published in the Journal of Medical Toxicology , the official journal of the American College of Medical Toxicology

But power doesnt need to mean aggression