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Conflicts of interest declared by the authors : Mar Guilarte has participated as a principal investigator in clinical trials sponsored by CSL Behring, Takeda, Pharvaris, Jerini AG/Shire, Pharming NV, BioCryst, Biomarin, Ionis, and Kalvista

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Most patients experience symptomatic improvement within 1-2 weeks, with objective measures improving over 4-8 weeks

All these factors contribute to the depletion of vitamins and antioxidants

While semaglutide pens are designed for single-patient use and contain preservatives, using them beyond their safe timeframe increases contamination risk

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