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These drugs are part of an emerging class of nutrient-stimulated hormone-based therapeutics that act as incretin mimetics, targeting G-proteincoupled receptors such as GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon, which are crucial in body fat and energy balance regulation

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Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats1