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Although the structure of the intestinal microbiota is very complex and the experimental design varies among studies, such as the different timing of HFD induction, distinctions in the duration of metformin treatment, and variations in mouse strains, but the impact of metformin on gut microbiota derived from these studies are nearly consistent

Those APCs that violate the 2 times rule are identified and appear in Table 16

Endometriosis Endometriosis Last Section Update: 02/2026 Contributor(s) : Alexandra LaStella, Pharm.D, RPh

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