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The 0.5% discontinuation rate suggests most users will complete their treatment course without significant tolerability issues

However, retatrutide dose escalation schedules differ from tirzepatide, starting at lower doses and escalating more gradually in many research protocols

Weight cycling or yo-yo-ing has a negative effect on metabolism, and is really hard on body image and self-esteem

As the body becomes smaller, the face may also lose some of the fullness that previously supported its contours

Shake well before consumption