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For instance, Zhou et al

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Additionally, ROS can react with unsaturated fatty acids on lipid membranes, leading to the production of free radicals and inducing fatty acid peroxidation, resulting in the generation of fatty acid-ROS (48)

Binding of histamine to these receptors initiates a complex cascade of intracellular signaling events that activate itch-specific neuronal pathways, ultimately resulting in the perception of itching and the induction of scratching behavior