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severe ongoing nausea, vomiting, or diarrhea

Injectable pens and needles should be disposed of in FDA-cleared sharps containers, never in household trash or recycling

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For clinics that use or emphasize compounded drugs, availability can vary by state and pharmacy, and compounded GLP-1s are not FDA approved

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Furthermore, the osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor B Ligand (RANKL) pathway is regulated by GLP-1RAs, increasing the OPG/RANKL ratio to inhibit osteoclast formation and promote bone formation by upregulating osteogenic genes like OC, COL1, Runx2, and ALP [120, 121]