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Risk Factors That May Increase Depression Risk on GLP-1 Patients with a personal or family history of depression, bipolar disorder, or other mood disorders should receive enhanced mental health screening before starting GLP-1 therapy

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A provider may consider: IGF-1 Fasting glucose A1C Lipids Thyroid markers Liver and kidney markers Blood pressure Sleep quality Current medications Personal and family health history Lab review helps determine whether growth hormone support is appropriate, whether a safer alternative should be considered, and how treatment should be monitored over time

Dual GLP1 and GIP agonists Tirzepatide is a once weekly, subcutaneous, unimolecular dual RA (GLP-1 and GIP) which has comparable GIP receptor binding affinity to native GIP and 5 times lower GLP-1 receptor affinity than that of native GLP-1