Early trials reported it to be generally well tolerated at low doses, but these studies were small and of short duration
[ \- Link Opens in New Tab]( National Institutes of Health, Office of Dietary Supplements
When to Seek Professional Guidance Consult a healthcare professional if: You suspect B12 deficiency You experience neuropathy symptoms in the feet You want to explore B12 nerve-targeted injection programmes B12 injections in the foot and ankle are most effective when part of a comprehensive neuropathy care plan , including nutrition, lifestyle, and medical support
This article reports what the clinical literature supports, where evidence is preliminary, what realistic expectations look like, and the genetic variables that shape individual response
Combined nicotinamide N-methyltransferase inhibition and lean-diet substitution reduces body weight and liver fat in obese mice
Nature 542 , 352356 (2017)