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In thalassemia patients, the dysregulation of the glutathione antioxidant system can exacerbate the effects of iron overload

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Activation of Nrf2 and a subsequent induction of GCL have been reported for various oxidants and electrophiles such as DEM, H 2 O 2 , quinones, 4-hydroxynonenal, methyl mercury, arsenicals, and plasmonic gold nanoparticles (Zhang et al

Novel drugs that upregulate FSP1 expression may be used to treat iron-related diseases