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Gao Y, Kong F, Song X, Shang J, Yao L, Xia J, Peng Y, Liu W, Gong H, Mu M, Cui H, Han T, Chen W, Wu X, Yang Y, Yan X, Jin Z, Wang P, Zhu Q, Chen L, Zhao C, Zhang D, Jin W, Wang D, Wen X, Liu C, Jia J, Mao Q, Ding Y, Jin X, Zhang Z, Mao Q, Li G, Niu J
non-antioxidant roles
A 50 mg/ml dose of pycnogenol and a 12 hr pre-treatment time provided maximal 70% inhibition of inducible ICAM-1 expression in HaCaT cells ( Table 1 ) [84]
While animal models and in vitro cultures provided the "proof of concept," the 2026 reclassification has allowed for the validation of these mechanisms in human clinical settings
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