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In individuals with T2D and CKD, it is advisable to contemplate the utilization of an SGLT2 inhibitor for additional cardiovascular risk mitigation when the eGFR and UACR levels are at or above 25 mL/min/1.73 m2 or 300 mg/g, respectively

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10.2337/db18-1465-P Diabetes

Endothelial-to-mesenchymal transition is induced by high glucose, TGF- signaling, and inflammatory cytokines, and is implicated in fibrosis and plaque instability (33, 34)

T2DM: Type 2 Diabetes Mellitus Industry-sponsored trials are actively underway (or have already been completed) exploring the potential for GLP-1 based therapies in a range of new indications