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Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)

It may interfere with the treatments effectiveness

Slow gastric emptying: They signal certain nerves to slow down the movement of food from the stomach into the intestine

HbA1c levels declined steadily in the semaglutide groups until around week 20, after which they plateaued

This is done by the CYP 2D6 microsomal enzyme of which there are 5-6 pharmogenetically active forms ranging from ultra-slow to ultra-fast

The findings of these studies combined clearly suggests that early management with GLP-1 receptor agonists may successfully prevent the development from simple steatosis to more serious liver disease