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Semaglutide is a GLP-1 receptor agonist that slows gastric emptying and stimulates brainstem receptors involved in nausea Nausea affects at least 10% of patients and is dose-dependent, often improving after several weeks of continued treatment Dietary modifications, smaller frequent meals, and gradual dose escalation help reduce gastrointestinal side effects Severe persistent vomiting, inability to retain fluids, or severe abdominal pain warrant immediate medical assessment Rare serious complications include pancreatitis, gallbladder disease, and dehydration-related kidney problems requiring urgent review Table of Contents Does Ozempic Make You Feel Sick

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