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You may need to consult your provider first if you: Have a known allergy to cobalt or B12 Have kidney disease or Lebers optic neuropathy Are pregnant or breastfeeding (dosing may be adjusted) What do I need to know before my appointment

Limitations This review is subject to several limitations inherent in the included studies as great evidence is derived from animal and in-vitro models of PD

Systemic copper absorption from creams and serums is minimal

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In terms of cost, the IM route is higher in cost than the SL and oral routes [2, 55]