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Even moderate intake (23 drinks weekly) can suppress hepatic glutathione by 1520% for 4872 hours post-consumption

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By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism

10.3760/cma.j.cn112148-20210920-00807 83 QuirogaR.NistalE.EstbanezB.PorrasD.Jurez-FernndezM.Martnez-FlrezS.et al (2020)

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Health authorities discourage its use due to insufficient human safety data, and some jurisdictions have restricted it as a prescription-only medicine despite it not being available through legitimate prescriptions