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NADPH has the effect of eliminating reactive oxygen species (ROS) in the body, and IDH1 mutation weakens its ability to eliminate ROS

Much of the evidence remains anecdotal or derived from animal studies, emphasizing the importance of caution and professional guidance

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Subacute CLE: features of lupus noted in the epidermis and superficial dermis Chronic discoid CLE: typical features of lupus with atrophy and scarring Direct immunofluorescence is positive in sun-protected healthy skin in SLE Blood tests Multiple autoantibodies are typically present in SLE, often in high titre (see immunological criteria above)

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