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Disruptions in iron homeostasis in the brain can also be a risk factor or exacerbate neuropsychiatric conditions, including depression, anxiety, and cognitive impairments (Lotan et al., 2023

The table lists metformin at roughly 2 to 3 kg over 12 months, and GLP-1 agonists such as semaglutide at 5 to 15 kg over 6 to 12 months, described as dose-dependent

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Lowering inflammatory cytokines Studies in Nature and Diabetes show that GLP-1 reduces cytokines such as TNF-alpha, IL-6, and IL-1, which are major players in autoimmune diseases and arthritis