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Research in rodent models has characterized MC4R-mediated effects on food intake suppression, energy expenditure, and autonomic outflow, establishing MT-2 as a widely used pharmacological tool for probing central melanocortin circuitry (Huszar et al., Cell, 1997

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[DOI] [PMC free article] [PubMed] [Google Scholar] Fukuyama Y., Nakajima C., Izumi S., Tanaka K