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The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a ammonium formate buffer

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153 Noise can damage cochlear tissues through a variety of mechanisms that are also factors in age-related hearing loss, such as increased inflammation and free radical production, disordered calcium metabolism in the inner ear, altered cell signaling, and programmed cell death, all of which have been implicated in hair cell and auditory neuron damage

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As a result, oxidative inactivation of enzymes involved in the mitochondrial respiratory chain can create a detrimental feedback loop [41]

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