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At the basolateral membrane, NBC1 (Na + -bicarbonate cotransporter 1: encoded by the SLC4A4 gene) effluxes HCO 3 , made de novo intracellularly via CAII, to the blood

When food moves more slowly through the intestines, there may be increased opportunity for bacterial fermentation of undigested carbohydrates in the colon, potentially leading to greater gas production

Discussion Although numerous studies have shown that cardiac energy metabolism is altered in pathological cardiac remodeling and that the resulting myocardial energy deficit can lead to further HF, there is minimal research on therapeutic targets and drugs based on this energy shift 2,38