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GLP-1 clinical guidance broadly recommends combining medication with lifestyle changes including physical activity to support results and minimize muscle loss

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Research suggests tirzepatide preserves lean muscle mass more effectively than GLP-1-only compounds, though this remains an active area of investigation

Pharmacies should provide purity and sterility testing upon request, says Bonilla

The FDA's overview of GLP-1 medications also highlights the importance of using these medications under appropriate medical supervision