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While early studies centred on cases obtained from institutionalised psychiatric settings [92, 93, 98], cases were later recruited through internal research registers [64], multiple centres [47, 50, 64, 70, 71, 88, 95, 96] or community advertisements [75]

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With an aim to understand how decreased GNE expression might affect sialylation and function of IGF-1R, we first determined sialylation levels of IGF-1R in GNE knockdown cells by immunoblotting

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