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Cell 117(3):399412 Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

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Resting metabolic rate can drop by 15%20% in people with untreated or undertreated hypothyroidism, meaning the body burns significantly fewer calories at rest than it would with normal thyroid function

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