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Metformin was a major candidate, but multiple trials showed no improvement regarding steatosis, inflammation or fibrosis, despite a significant reduction of liver enzymes

For best results, Semaglutide should be used in conjunction with other weight loss strategies rather than as a quick fix

Shirani et al., 2025)

High relative potency GLP-1 Influences appetite, fullness, energy intake, gastric emptying and glucose regulation

However, it may be that the evaluation of cerebral glucose metabolism is a valuable marker for evaluating how the brain of MS patients is responding to therapies that target neuronal function

Others may include them, but with extra steps before approval