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The BMP/Smad pathway effect is counteracted by the transplantation of MSCs derived from bone marrow (BMSCs), which promote NSC differentiation into OLs, the myelinating glia of the CNS (Sandner et al., 2013

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However, influenced by various signaling pathways, HSP70 upregulation is driven primarily by heat shock factors, particularly HSF1, which are involved in a complex regulatory network (Figure 2)

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