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Additionally, downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a crucial regulator of the cellular antioxidant response, compromises the hepatocytes first-line defence against oxidative injury [50, 51]

Were used to seeing hyperammonemia in patients with cirrhosis , which is less dangerous and carries little clinical significance (over time, patients with cirrhosis adapt to chronically elevated ammonia levels)

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But because so many people are taking semaglutide, they think the findings warrant further study and urgent clarification about the risk

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