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Emerging evidence indicates that vitamin D, through receptor-mediated signaling, participates in multiple pathophysiological processes, including the regulation of immune and inflammatory responses, the mitigation of oxidative stress, the preservation of mitochondrial function, the inhibition of renal fibrosis, modulation of the reninangiotensinaldosterone system (RAAS), and the maintenance of gutkidney axis homeostasis

10.3389/fnins.2020.00131 317 MenozziE.SchapiraA

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Perimenopause is the four- to seven-year period prior to menopause when women are having menopausal symptoms

Longer-lasting, sometimes preferred for patients with active detoxification goals