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Infant gut microbiota: developmental influences and health outcomes

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Loss of Kindlin-3 in LAD-III eliminates LFA1 but not VLA-4 adhesiveness developed under shear flow conditions

Specifically, changes in gut microbiota diversity can affect epidermal differentiation pathways, immune regulation, inflammatory signaling, and barrier integrity mediated by microbial metabolites, ultimately destabilising skin immune homeostasis [93]