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Interactions between multiple drugs and diseases can complicate optimal management and control of chronic conditions, including drug-drug interactions and adverse drug reactions [26, 27]

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30 Impaired mitophagy contributes to cardiac dysfunction and fibrosis in obesity, primary cardiomyopathies, and HIV-associated cardiomyopathy (HIVAC)

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Since cortisol secretion also follows a regular circadian pattern roughly opposite to that of melatonin, this finding provides additional confirmation of possible day-night cycle disturbance in women with PCOS

More studies are needed that directly compare the effects of each