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Furthermore, the concentration of several metabolites was higher in the 4+1 group compared to the other two treated and control groups except for L-cysteine, D-glucose, L-glutamic acid, and pyruvate, which were lower ( Figure 1B and Figure 2 )

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Nonetheless, it is unquestionable that BA intakes in excess of dietary intake are required to elicit significant carnosine increases (39), meaning supplementation with BA is the most effective and practical means by which to increase muscle carnosine content

Ferroptosis represents a promising therapeutic avenue, as its core mechanisms align with the metabolic dependencies of PDAC

The STEP trials (20212023) demonstrated that semaglutide produces 1522% body-weight loss over 68 weeks when combined with lifestyle changes, compared to 23% weight loss with placebo

doi: 10.1016/j.postharvbio.2015.12.005 84 ShanY.ZhangD.LuoZ.LiT.QuH.DuanX.et al